Literature References
Covalent Inhibition
Advances in covalent drug discovery
Lydia Boike, Nathaniel J. Henning, Daniel K Nomura
Nature Review Drug Discovery – 2022 Aug 25
https://pubmed.ncbi.nlm.nih.gov/36008483/
The ascension of targeted covalent inhibitors
Juswinder Singh
Journal of Medicinal Chemistry – 2022 Apr 19
https://pubmed.ncbi.nlm.nih.gov/36008483/
The design and development of covalent protein-protein interaction inhibitors for cancer treatment
Sha-sha Cheng, Gua-Jun Yang, Wanhe Wang, Chung-Hang Leung & Dik-Lung Ma
Journal of Hematology & Oncology – 2020 Mar 30
https://doi.org/10.1186/s13045-020-00850-0
Perspective on the kinetics of covalent and irreversible inhibition
John M. Strelow
SLAS Discovery – 2017 Jan
https://doi.org/10.1177/1087057116671509
Drug discovery for a new generation of covalent drugs
Amit S. Kalgutkar & Deepak K. Dalvie
Expert Opinion on Drug Discovery – 2012 May 19
https://doi.org/10.1517/17460441.2012.688744
Diabetes and Beta Cell Function
Type 2 diabetes-a matter of beta-cell life and death?
Christopher J. Rhodes
Science – 2005 Jan 21
307(5708):380-4. doi: 10.1126/science.1104345. PMID: 15662003.
https://pubmed.ncbi.nlm.nih.gov/15662003/
Diabetes Invest_Beta-cell failure in diabetes – Common susceptibility and mechanisms shared between type 1 and type 2 diabetes 1
Hiroshi Ikegami, Naru Babaya, and Shinsuke Noso
Journal of Diabetes Investigation – 2021 Sep;
12(9): 1526–1539. Published online 2021 Jun 16. doi: 10.1111/jdi.13576
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409822/
Not control but conquest – Strategies for the remission of Type 2 diabetes mellitus
Jinyoung Kim, Hyuk-Sang Kwon
Diabetes and Metabolism Journal – 2022 Mar;
46(2):165-180. doi: 10.4093/dmj.2021.0377.
https://pubmed.ncbi.nlm.nih.gov/35385632/
Increased beta-cell proliferation before immune cell invasion prevents progression of Type 1 diabetes
Dirice E et al., 2019 Nature Metabolism
Nat Metab – 2019 May
1(5): 509–518. Published online 2019 May 6. doi: 10.1038/s42255-019-0061-8
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696912/
Importance of beta cell mass for glycaemic control in people with Type 1 diabetes
Shuai Hao et al.
Endocrinology Metabolism Clinics of North America – 2023 Mar
52(1):27-38. doi: 10.1016/j.ecl.2022.07.003. Epub 2022 Nov 14.
https://pubmed.ncbi.nlm.nih.gov/36754495/
Intervention with therapeutic agents, Understanding the path to remission in Type 2 diabetes – Part 2
Shuai Hao et al.
Endocrinology Metabolism Clinics of North America – 2023 Mar
52(1):39-47. doi: 10.1016/j.ecl.2022.07.004. Epub 2022 Nov 18.
https://pubmed.ncbi.nlm.nih.gov/36754496/
Beta Cell Proliferation
Pancreatic β-cell proliferation in obesity
Linnemann AK, Baan M, Davis DB
Advances in Nutrition – 2014 May 14, 5(3):278-88. doi: 10.3945/an.113.005488. PMID: 24829474; PMCID: PMC4013180.
https://pubmed.ncbi.nlm.nih.gov/24829474/
A morphological study of the endocrine pancreas in human pregnancy
F.A. Van Assche FA, L. Aerts L, F. De Prins
British Journal of Obstet Gynaecology – 1978 Nov, 85(11):818-20. doi: 10.1111/j.1471-0528.1978.tb15835.x. PMID: 363135.
https://pubmed.ncbi.nlm.nih.gov/363135/
Beta cell adaptation to pregnancy requires prolactin action on both beta and non-beta cells
Shrivastava V, Lee M, Lee D, Pretorius M, Radford B, Makkar G, Huang C.
Scientific Reports – 2021 May 14, 11(1):10372. doi: 10.1038/s41598-021-89745-9. PMID: 33990661; PMCID: PMC8121891.
https://pubmed.ncbi.nlm.nih.gov/33990661
Prolactin-regulated Pbk is involved in pregnancy-induced β-cell proliferation in mice
Cao, Y., Feng, Z., He, X., Zhang, X., Xing, B., Wu, Y., Hojnacki, T., Katona, B. W., Ma, J., Zhan, X., & Hua, X. (2022)
Journal of Endocrinology, 252(2), 107-123.
https://doi.org/10.1530/JOE-21-0114
Expansion of β-cell mass in response to pregnancy
Sebastian Rieck and Klaus H. Kaestner
Trends in Endocrinology and Metabolism – 2010, Mar 21, (3):151-8. doi: 10.1016/j.tem.2009.11.001. Epub 2009 Dec 16.
https://pubmed.ncbi.nlm.nih.gov/20015659/
Beta-cell compensation and gestational diabetes
Taofeek O Usman, Goma Chhetri, Hsuan Yeh, H Henry Dong
Journal of Biological Chemistry – 2023, Dec, 299(12):105405. doi: 10.1016/j.jbc.2023.105405. Epub 2023 Oct 29.
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Serum from pregnant donors induces human beta cell proliferation and insulin secretion
Sylvester-Armstrong KR et al.
bioRxiv – 2023, Apr 17, 2023.04.17.537214. doi: 10.1101/2023.04.17.537214
https://pubmed.ncbi.nlm.nih.gov/37131658/
Modulatory role of prolactin in type 1 diabetes
Ramos-Martínez E et al.
Hormone Molecular Biology and Clinical Investigation – 2022, Jul 19, 44(1):79-88. doi: 10.1515/hmbci-2022-0008. eCollection 2023 Mar 1.
https://pubmed.ncbi.nlm.nih.gov/35852366/
Pancreatic islet cell type-specific transcriptomic changes during pregnancy and postpartum
Chung J-Y et al.
iScience – 2023 Mar 17, 26(4):106439. doi: 10.1016/j.isci.2023.106439. eCollection 2023 Apr 21.
https://pubmed.ncbi.nlm.nih.gov/37020962/
Breastfeeding can reduce the risk of developing diabetes
Soo Young Kim
Korean Journal of Family Medicine – 2018, 39(5):271-272. Published online: September 20, 2018 DOI: https://doi.org/10.4082/kjfm.39.5E
https://www.kjfm.or.kr/journal/view.php?number=4371
Potential protective effect of lactation against incidence of type 2 diabetes mellitus in women with previous gestational diabetes mellitus
Tanase-Nakao K et al.
Diabetes Metab Res Review – 2017 May, 33(4): e2875. Published online 2017 Feb 23. doi: 10.1002/dmrr.2875
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434910/
Lactation and progression to type 2 diabetes in patients with gestational diabetes mellitus – A systematic review and meta-analysis of cohort studies
Feng L et al.
Journal of Diabetes Investigation – 2018 Nov 9, 9(6):1360-1369. doi: 10.1111/jdi.12838. Epub 2018 Apr 18.
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Lactation and progression to Type 2 diabetes mellitus after gestational diabetes mellitus – A prospective cohort study
Gunderson EP et al.
Annals of Internal Medicine – 2015 Dec 15, 163(12):889-98. doi: 10.7326/M15-0807. Epub 2015 Nov 24.
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Prior lactation reduces future diabetic risk sustained postweaning effects on insulin sensitivity
Bajaj H et al.
American Journal of Physiology: Endocrinology and Metabolism – 2017 Mar 1, 312(3):E215-E223. doi: 10.1152/ajpendo.00403.2016. Epub 2016 Dec 13.
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Association of lactation with maternal risk of type 2 diabetes – A systematic review and meta-analysis of observational studies
Pinho‐Gomes A-C et al.
Diabetes, Obesity and Metabolism – 2021 Aug, 23(8):1902-1916. doi: 10.1111/dom.14417. Epub 2021 May 20.
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Lactation duration and progression to diabetes in women across the childbearing years – The 30-year CARDIA study
Gunderson EP et al.
JAMA Internal Medicine – 2018 Mar, 178(3): 328–337. Published online 2018 Jan 16. doi: 10.1001/jamainternmed.2017.7978
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Effect of breastfeeding and its duration on impaired fasting glucose and diabetes in perimenopausal and postmenopausal women – Korea National Health and Nutrition Examination Survey (KNHANES)
Kwan B-S et al.
Medicines – 2021 Nov 12, 8(11):71.doi: 10.3390/medicines8110071.
https://pubmed.ncbi.nlm.nih.gov/34822368/
Menin and Beta Cell Proliferation
Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c
Karnik, S. K., Hughes, C. M., Gu, X., Rozenblatt-Rosen, O., McLean, G. W., Xiong, Y., Meyerson, M., & Kim, S. K.
Proceedings of the National Academy of Sciences of the United States of America – 2005, 102(41), 14659–14664.
https://doi.org/10.1073/pnas.0503484102
Reversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene
Yang, Y., Gurung, B., Wu, T., Wang, H., Stoffers, D. A., & Hua, X.
Proceedings of the National Academy of Sciences of the United States of America – 2010, 107(47), 20358–20363.
https://doi.org/10.1073/pnas.1012257107
Deletion of the Men1 gene prevents streptozotocin-induced hyperglycemia in mice
Yang Y, Wang H, Hua X. .
Proceedings of the National Academy of the Sciences, US – 2011 Jan 17, 2010:876701. doi: 10.1155/2010/876701. Epub 2011 Jan 17. PMID: 21318185; PMCID: PMC3034935
https://pubmed.ncbi.nlm.nih.gov/21059956/
Glucose-mediated repression of menin promotes pancreatic β-cell proliferation
Zhang, H., Li, W., Wang, Q., Wang, X., Li, F., Zhang, C., Wu, L., Long, H., Liu, Y., Li, X., Luo, M., Li, G., & Ning, G. Endocrinology – 2012, 153(2), 602–611.
https://doi.org/10.1210/en.2011-1460
Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus
Karnik, S. K., Chen, H., McLean, G. W., Heit, J. J., Gu, X., Zhang, A. Y., Fontaine, M., Yen, M. H., & Kim, S. K.
Science (New York, N.Y.) – 2007, 318(5851), 806–809.
https://doi.org/10.1126/science.1146812
Menin-regulated Pbk controls high fat diet-induced compensatory beta cell proliferation
Ma, J., Xing, B., Cao, Y., He, X., Bennett, K. E., Tong, C., An, C., Hojnacki, T., Feng, Z., Deng, S., Ling, S., Xie, G., Wu, Y., Ren, Y., Yu, M., Katona, B. W., Li, H., Naji, A., & Hua, X.
EMBO molecular medicine – 2021, 13(5), e13524.
https://doi.org/10.15252/emmm.202013524
Participation of Akt, menin, and p21 in pregnancy-induced beta-cell proliferation.
Hughes, E., & Huang, C.
Endocrinology – 2011, 152(3), 847–855.
https://doi.org/10.1210/en.2010-1250
Combined inhibition of menin-MLL interaction and TGF-β signaling induces replication of human pancreatic beta cells
Pahlavanneshan S et al.
European Journal of Cell Biology – 2020 Jun;99(5):151094.doi: 10.1016/j.ejcb.2020.151094. Epub 2020 May 30.
https://pubmed.ncbi.nlm.nih.gov/32646642/
Induction of ß Cell Replication by Small Molecule-Mediated Menin Inhibition and Combined PKC Activation and TGF‑ß Inhibition as Revealed by A Refined Primary Culture Screening
Pahlavanneshan S et al.
Cell Journal – 2021 Nov;23(6):633-639.doi: 10.22074/cellj.2021.7437. Epub 2021 Nov 23.
https://pubmed.ncbi.nlm.nih.gov/34939756/
Epigenetic changes induced by high glucose in human pancreatic beta cells
Alhazzaa RA et al.
Journal of Diabetes Research – 2023 Feb 13:2023:9947294. doi: 10.1155/2023/9947294. eCollection 2023.
https://pubmed.ncbi.nlm.nih.gov/36815184/
VGLL4 and MENIN function as TEAD1 corepressors to block pancreatic β cell proliferation
Li F et al.
Cell Reports – 2023 Jan 31;42(1):111904.doi: 10.1016/j.celrep.2022.111904. Epub 2023 Jan 19.
https://pubmed.ncbi.nlm.nih.gov/36662616/
The potential of β‐cell growth promotion, continued
Zachary T. Bloomgarden
Journal of Diabetes – 2023 May; 15(5): 366–367. Published online 2023 Apr 27. doi: 10.1111/1753-0407.13396
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172018/
Menin Science
Menin dynamics and functional insight: take your partners
Molecular and Cellular Biology – 2010 Sep 15;326(1-2):80-4.doi: 10.1016/j.mce.2010.04.011. Epub 2010 Apr 24.
https://pubmed.ncbi.nlm.nih.gov/20399832/
The role of menin in hematopoiesis
Ivan Maillard and Jay L. Hess
Advances in Experimental Medicine and Biology – 2009:668:51-7.doi: 10.1007/978-1-4419-1664-8_5.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981825/
Regulation cyclin B2 expression and cell cycle G2-M transition by menin
Endocrinology and Metabolism – 01 Sep 2011
https://doi.org/10.1152/ajpendo.00022.2011
Epigenetic regulation by the menin pathway
Menin in Hematological Malignancies
Therapeutic implications of menin inhibition in acute leukemias
Issa, G. C., Ravandi, F., DiNardo, C. D., Jabbour, E., Kantarjian, H. M., & Andreeff, M.
Leukemia – 2021, 35(9), 2482–2495.
https://doi.org/10.1038/s41375-021-01309-y
Challenges and opportunities in targeting the menin–MLL interaction
Cierpicki, T., & Grembecka, J.
Future Medicinal Chemistry – 2014, 6(4), 447–462.
https://doi.org/10.4155/fmc.13.214
The Spectrum of MYC Alterations in Diffuse Large B-Cell Lymphoma
Xia, Y., & Zhang, X.
Acta haematologica – 2020, 143(6), 520–528.
https://doi.org/10.1159/000505892
Targeting MYC in multiple myeloma
Jovanović, K. K., Roche-Lestienne, C., Ghobrial, I. M., Facon, T., Quesnel, B., & Manier, S.
Leukemia – 2018, 32(6), 1295–1306.
https://doi.org/10.1038/s41375-018-0036-x
Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia
Kuhn, M. W. M., Song, E., Feng, Z., Sinha, A., Chen, C.-W., Deshpande, A. J., … Armstrong, S. A.
Cancer Discovery – 2016, 6(10), 1166–1181.
https://doi.org/10.1158/2159-8290.CD-16-0237
Menin in Solid Tumors
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription
JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer
https://pubmed.ncbi.nlm.nih.gov/34236045/